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A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus

Frontiers of Medicine doi: 10.1007/s11684-023-1011-0

Abstract: We aimed to investigate the safety and efficacy of nirmatrelvir/ritonavir (Paxlovid) therapy for hemodialysis-dependent patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Thirteen hemodialysis patients infected with the Omicron variant of SARS-CoV-2 from April 3 to May 30, 2022, were recruited. Laboratory parameters and chest CT (computed tomography) imaging were analyzed. The treatment group included six patients who received 150 mg/100 mg of Paxlovid orally once daily for 5 days, whereas the control group included seven patients who received basic treatment. No serious adverse reactions or safety events were recorded. Four control patients progressed to moderate disease, and none in the treatment group showed progression of chest CT findings (P < 0.05). Paxlovid therapy tended toward early viral clearance and low viral load on Day 8. Moreover, 83.3% of the patients in the treatment group and 57.1% of the patients in the control group turned negative within 22 days. In the Paxlovid treatment group, we found significantly increased levels of lymphocytes (P=0.03) and eosinophils (P=0.02) and decreased levels of D-dimer on Day 8 compared with those on Day 1. Paxlovid therapy showed a potential therapeutic effect with good tolerance in hemodialysis patients. The optimal dose and effectiveness evaluation must be further investigated in a largeer cohort.

Keywords： Paxlovid     hemodialysis     SARS-CoV-2     viral load     chest CT scan    

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Same stimuli, different responses: a pilot study assessing air pollution visibility impacts on emotional

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1620-5

Abstract:

● Emotional responses to visibility-reducing haze was assessed in a controlled lab.

Keywords： Air pollution     Emotional wellbeing     Variability     Visual exposure     Emotional bias    

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Using loose nanofiltration membrane for lake water treatment: A pilot study

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1362-6

Abstract:

• A pilot study was conducted for drinking water treatment using loose

Keywords： Nanofiltration     Drinking water     Membrane fouling     Aluminum carryover     Chemical cleaning    

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preozonation on the bioactivity and biodiversity of subsequent biofilters under low temperature conditions—A pilotstudy

Jiaxuan YANG, Jun MA, Dan SONG, Xuedong ZHAI, Xiujuan KONG

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 4, doi: 10.1007/s11783-016-0844-z

Abstract: The bioactivity was enhanced by preozonation under low temperature conditions. Higher level of BDOC/AOC and DO may enhance the nitrifying performance. High level of biodiversity and bioactivity may help maintain the stability of filters. Water quality and DO could selectively enhance different microbial communities. The combination of preozonation and subsequent biological granular activated carbon (O /BAC) filtration is well known as a promising method for the removal of many pollutants. Temperature and nutrients are the dominant factors in external conditions to influence the biological communities. To explore the influence of preozonation under low temperature, the factors such as dissolved oxygen (DO), dissolved organic carbon (DOC) and NH -N were analyzed from the sampling ports every week; triphenyl tetrazolium chloride-dehydrogenase activity (TTC-DHA) and the nitrifying activity were detected along the bed height of biofilter at four levels (10, 40, 70 and 110 cm) on the 90th, 110th, and 130th day; microbial community, based on 16S rRNA gene-denaturing gradient gel electrophoresis (DGGE), was monitored on the 130th day of the operation. The observed microbial property showed that preozonation had a positive influence on bioactivity, biomass and nitrifying activity. Community analysis showed no significant difference on the biodiversity of nitrifying bacteria between the parallel filters in the inlet end based on the method employed. This result showed that biofilters’ performance is not correlated well with microbial biodiversity. The elevated functionality in O /BAC filters can be a result of increased microbial activity, which was promoted by preozonation.

Keywords： Preozonation     BAC filtration     High ammonia level     Bacterial activity     Microbial community structure     Pilotscale study    

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comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilotdouble-blind, randomized, and placebo-controlled study

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 736-744 doi: 10.1007/s11684-021-0870-5

Abstract: A pilot study on TCM syndrome differentiation can evaluate the clinical efficacy and safety of TCM andOnly 83 patients from the 96 patients with pneumoconiosis finished the study.This study showed that TCM syndrome differentiation and treatment had a favorable impact on the exercise

Keywords： pneumoconiosis     randomized controlled trials     traditional Chinese medicine    

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Increasing the performance of anaerobic digestion: Pilot scale experimental study for thermal hydrolysis

S.I. PEREZ-ELVIRA, M. FDZ-POLANCO, F. FDZ-POLANCO,

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 2,   Pages 135-141 doi: 10.1007/s11783-010-0024-5

Abstract: The performance of a pilot plant operation combining thermal hydrolysis (170°C, 30 min) and

Keywords： anaerobic digestion (AD)     biogas     performance     sludge     thermal hydrolysis    

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Removal of arsenic by pilot-scale vertical flow constructed wetland

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-021-1435-1

Abstract:

• VFCWs are effective for the treatment of arsenic-containing wastewater.

Keywords： Constructed wetland     Arsenic     Removal efficiency     Mass balance    

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A pilot scale test of ozonization treatment of ethene wastewater for reuse

ZHONG Li, REN Wei, GUO Wenjing

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 2,   Pages 191-195 doi: 10.1007/s11705-008-0028-x

Abstract: A pilot scale test of advanced treatment of ethene wastewater by ozonization was carried out for industrial

Keywords： different     industrial     oxygen     generation     criterion    

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process and sulfide precipitation for removal of heavy metals from industrial wastewater: Bench and pilot

Huosheng Li, Hongguo Zhang, Jianyou Long, Ping Zhang, Yongheng Chen

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1130-7

Abstract:

Bench and pilot studies demonstrated the effectiveness

Keywords： Thallium     Pilot     Fenton     Sulfide precipitation     Heavy metal     Industrial wastewater    

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Flow characteristic and wastewater treatment performance of a pilot-scale airlift oxidation ditch

Hongtao PANG, Hanchang SHI, Huiming SHI,

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 4,   Pages 470-476 doi: 10.1007/s11783-009-0143-z

Abstract: A pilot-scale airlift oxidation ditch using bubble diffuser and baffle as aerator was operated in a wastewater

Keywords： airlift oxidation ditch     flow characteristic     wastewater treatment    

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Pilot study for the treatment of sodium and fluoride-contaminated groundwater by using high-pressure

Xiaomao WANG,Hongwei YANG,Zhenyu LI,Shaoxia YANG,Yuefeng XIE

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 1,   Pages 155-163 doi: 10.1007/s11783-014-0740-3

Abstract: This paper reports a pilot study in treating a typical groundwater in Huaibei Plain containing excessiveRO), four low-pressure RO (LPRO) and one tight nanofiltration (NF) membranes were tested under this pilotstudy.

Keywords： reverse osmosis (RO)     nanofiltration (NF)     water quality standards     sodium     fluoride     cost estimation    

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Ignition delay of dual fuel engine operating with methanol ignited by pilot diesel

ZOU Hongbo, WANG Lijun, LIU Shenghua, LI Yu

Frontiers in Energy 2008, Volume 2, Issue 3,   Pages 285-290 doi: 10.1007/s11708-008-0060-z

Abstract: An investigation on the ignition delay of a dual fuel engine operating with methanol ignited by pilotthe ignition delay of the dual fuel engine increases remarkably by advancing the delivery timing of pilot
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processes on zero-valent iron modified biochar in copper(II) immobilization: from batch solution to pilot-scale

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 880-892 doi: 10.1007/s11705-022-2282-8

Abstract: The zero-valent iron modified biochar materials are widely employed for heavy metals immobilization. However, these materials would be inevitably aged by natural forces after entering into the environment, while there are seldom studies reported the aging effects of zero-valent iron modified biochar. In this work, the hydrogen peroxide and hydrochloric acid solution were applied to simulate aging conditions of zero-valent iron modified biochar. According to the results, the adsorption capacity of copper(II) contaminants on biochar, zero-valent iron modified biochar-1, and zero-valent iron modified biochar-2 after aging was decreased by 15.36%, 22.65% and 23.26%, respectively. The surface interactions were assigned with chemisorption occurred on multi-molecular layers, which were proved by the pseudo-second-order and Langmuir models. After aging, the decreasing of capacity could be mainly attributed to the inhibition of ion-exchange and zero-valent iron oxidation. Moreover, the plant growth and soil leaching experiments also proved the effects of aging treatment, the zero-valent iron modified biochar reduced the inhibition of copper(II) bioavailability and increased the mobility of copper(II) after aging. All these results bridged the gaps between bio-adsorbents customization and their environmental behaviors during practical agro-industrial application.

Keywords： zero-valent iron modified biochar     aging processes     copper removal     adsorption     pilot-scale experiments    

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Optimizing the configuration of a clearwell by integrating pilot and full-scale tracer testing

LIU Wenjun, DU Zhipeng, JIN Junwei

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 3,   Pages 270-275 doi: 10.1007/s11783-007-0045-x

Abstract: paper, the main factors impacting the plug flow pattern of a clearwell were investigated by integrating pilot-scaleIt was found that pilot tracer testing, full-scale tracer testing and CFD simulation all demonstratedThis study confirmed that the installation of baffles within clearwells is an efficient way to optimize
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Pilot plants of membrane technology in industry: Challenges and key learnings

Colin A. Scholes

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 3,   Pages 305-316 doi: 10.1007/s11705-019-1860-x

Abstract: into membrane technologies must be trialled in industrial processes, which requires membrane-based pilotThese pilot plants are critical to the commercialization of membrane technology, be it as gas separationHere, the author reports on his experience of operating membrane-based pilot plants for gas separationSpecifically, the challenges of developing and operating membrane pilot plants are presented, as wellas the key learnings on how to successfully manage membrane pilot plants to achieve desired performance

Keywords： membrane gas separation     membrane contactors     carbon capture     pilot plants     key learnings    

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Title Author Date Type Operation

A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus

Journal Article

Same stimuli, different responses: a pilot study assessing air pollution visibility impacts on emotional

Journal Article

Using loose nanofiltration membrane for lake water treatment: A pilot study

Journal Article

preozonation on the bioactivity and biodiversity of subsequent biofilters under low temperature conditions—A pilotstudy

Jiaxuan YANG, Jun MA, Dan SONG, Xuedong ZHAI, Xiujuan KONG

Journal Article

comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilotdouble-blind, randomized, and placebo-controlled study

Journal Article

Increasing the performance of anaerobic digestion: Pilot scale experimental study for thermal hydrolysis

S.I. PEREZ-ELVIRA, M. FDZ-POLANCO, F. FDZ-POLANCO,

Journal Article

Removal of arsenic by pilot-scale vertical flow constructed wetland

Journal Article

A pilot scale test of ozonization treatment of ethene wastewater for reuse

ZHONG Li, REN Wei, GUO Wenjing

Journal Article

process and sulfide precipitation for removal of heavy metals from industrial wastewater: Bench and pilot

Huosheng Li, Hongguo Zhang, Jianyou Long, Ping Zhang, Yongheng Chen

Journal Article

Flow characteristic and wastewater treatment performance of a pilot-scale airlift oxidation ditch

Hongtao PANG, Hanchang SHI, Huiming SHI,

Journal Article

Pilot study for the treatment of sodium and fluoride-contaminated groundwater by using high-pressure

Xiaomao WANG,Hongwei YANG,Zhenyu LI,Shaoxia YANG,Yuefeng XIE

Journal Article

Ignition delay of dual fuel engine operating with methanol ignited by pilot diesel

ZOU Hongbo, WANG Lijun, LIU Shenghua, LI Yu

Journal Article

processes on zero-valent iron modified biochar in copper(II) immobilization: from batch solution to pilot-scale

Journal Article

Optimizing the configuration of a clearwell by integrating pilot and full-scale tracer testing

LIU Wenjun, DU Zhipeng, JIN Junwei

Journal Article

Pilot plants of membrane technology in industry: Challenges and key learnings

Colin A. Scholes

Journal Article